Padres vs Pirates Picks and Prediction – 5/4/2025

In Sunday afternoon MLB action, the San Diego Padres and the Pittsburgh Pirates will wrap up their weekend series from PNC Park. Be ready for the baseball season with all of our MLB predictions. The Padres (21-11) are riding a four-game winning streak and are a game back of Los Angeles for the top spot in the NL West Division standings. Last night, Fernando Tatis Jr. scored on a wild pitch in the ninth inning to propel San Diego to a 2-1 road victory. 

Thirty-two year old righty Nick Pivetta (5-1 1.78 ERA) will take the mound for the Padres in this matchup. San Diego has won Pivetta’s last four starts and he has allowed just four runs across his last 25 plus frames. 

The Pittsburgh Pirates are looking to snap a three-game losing streak and are stuck in the NL Central Division basement. During Saturday’s home loss, Pittsburgh was unable to take advantage of eight walks and left ten men in base. SP Bailey Falter allowed one run in seven innings and did not factor in the decision for the Pirates (12-22), who fell to 7-11 at home. 

Thirty-three year old southpaw Andrew Heaney (2-2 2.50 ERA) has quietly put together a nice first month for the Pirates. Through 36 innings of work, Heaney has fanned 31 batters and owns a minuscule 0.89 WHIP.

San Diego OF Jackson Merrill (hamstring) is currently on the 10-day injured list and could be activated as soon as Monday. Through 32 games, San Diego ranks 10th in OPS and 18th in runs scored. For the season, Pittsburgh ranks 26th in OPS and 25th in runs scored. Take the under. Final Score Prediction, San Diego Padres win 4-3.