Padres vs Marlins Picks and Prediction – 7/23/2025

In Wednesday afternoon MLB action, the San Diego Padres and the Miami Marlins will wrap up their series from loanDepot Park. Be ready for the baseball season with all of our MLB predictions. The Padres (55-46) are four games below .500 on the road and trail NL West Division leading Los Angeles by four games. Last night, San Diego OF Jackson Merrill had a two-run double in the ninth inning but was left stranded during a 4-3 road loss.

Twenty-nine year old righty Dylan Cease (3-9 4.64 ERA) will take the mound for the Padres in this matchup. In his last start, Cease (5.1 IP) fanned ten batters across five plus shutout frames during a 7-2 road victory against Washington.

The Miami Marlins have split their previous ten games and are sitting in third place in the NL East Division standings. During Tuesday’s home victory, C Agustin Ramirez went 2-for-4 with two runs scored to spark the Miami offense. SP Edward Cabrera (4-4) allowed one run across five plus frames to earn the win for the Marlins (47-53), who improved to 23-29 at home.  

2022 National League Cy Young Award winner Sandy Alcantara (4-9 7.14 ERA) has been unable to regain that form. Over his last five starts. Alcantara (29 IP) has been knocked around for 38 hits and 25 runs.

Miami 3B Connor Norby suffered a broken left hamate bone and will be sidelined for the next six-to-eight weeks. Through 101 games, San Diego ranks 23rd in OPS and 25th in runs scored. For the season, Miami ranks 20th in OPS and 19th in runs scored. Take the Padres to win on the road. Final Score Prediction, San Diego Padres win 5-3.