Padres vs Marlins Picks and Prediction – 7/22/2025

By: Eddie Kline |

Last Updated: 07/22/2025 at 12:24 AM ET

San Diego Padres at Miami Marlins 07/22/25 - MLB Picks & Predictions
Game Start: 7/22/2025, 10:40 PM UTC
Latest Odds: MIA -109 ; O/U 8

Padres vs Marlins Prediction

In Tuesday night MLB action, the San Diego Padres and the Miami Marlins will continue their series from loanDepot Park. Be ready for the baseball season with all of our MLB predictions. The Padres (55-45) have won seven of their last ten games and trail NL West Division leading Los Angeles by three games. Last night, San Diego OF Jackson Merrill had an RBI single and scored a run during a 2-1 road victory. All-Star closer Robert Suarez notched his 29th save for the Padres. 

Twenty-eight year old righty Stephen Kolek (3-4 4.24 ERA) will take the mound for the Padres in this matchup. Last time out, Kolek (5.1 IP) was tagged for nine hits and six runs during a 7-4 home loss versus Texas.

The Miami Marlins have split their previous ten games and are ten games off the pace in the NL East Division race. During Monday’s home loss, Miami batters went 0-for-5 with runners in scoring position and left six men on base. All-Star OF Kyle Stowers crushed his 22nd long ball for the Marlins (46-53), who fell to 22-29 at home. 

The Marlins will give the nod to hard-throwing righty Edward Cabrera (3-4 3.61 ERA) on Tuesday. Cabrera, who has been bothered by an elbow injury, has struck out 86 batters across 82 plus frames.

Padres vs Marlins Pick Analysis

San Diego SP Michael King (shoulder) threw a bullpen session on Thursday and hopes to return sometime next month. Through 100 games, San Diego ranks 23rd in OPS and 24th in runs scored. For the season, Miami ranks 19th in OPS and 19th in runs scored. Take the over. Final Score Prediction, Miami Marlins win 6-4.

Our Free MLB Pick for Miami Marlins vs San Diego Padres

OVER 8