Padres vs Astros Picks and Prediction – 4/19/2025

The San Diego Padres will be returning to Daikin Park on Friday, where they will take on the Houston Astros. Get the rest of our free MLB picks here! The San Diego Padres are ranked 1st according to ESPN early April rankings. The Padres are 2-1 in the last three games they played against Houston. Kyle Hart will be San Diego’s starting pitcher on Friday, he won his last start against Colorado. San Diego has the 1st ranked bullpen so far this season. Fernando Tatis Jr leads the Padres this year with a .348 batting average and 14 RBI. The Padres are 6-1 in their last seven games played.

The Houston Astros are ranked 21st according to ESPN early April rankings. Houston has been very competative playing against San Diego at home as they are 3-1 in the last four games played at Daikin Park. Ryan Gusto is headed to the mound for the Astros, he struggled allowing four hits and three runs in his last game pitched. Houston's bullpen is ranked 6th so far this season. Jose Altuve leads the Astros this season with 3 home runs, and 7 RBI. The Astros are 2-3 in their last five games played. 

The Padres have not done very well in Houston going 1-3 in the last four games at Daikin Park. The Padres have been better offensively as they have more hits and runs scored than Houston. San Diego will face right-hander Gusto and the Padres hit pretty well against righties. The Astros have struggled against left handed pitching so far this year. The Padres will score just enough to get the win. Final Score Prediction, San Diego Padres win 4-3.