Padres vs Tigers Picks and Prediction – 4/22/2025

Comerica Park will play host to a Tuesday night MLB interleague clash between the San Diego Padres and the Detroit Tigers. Be ready for the baseball season with all of our MLB predictions. The Padres (16-7) are two games below .500 on the road and are tied with the New York Mets for the best overall record in the majors. Last night, San Diego SP Randy Vasquez (1-2) was tagged for six runs and recorded just six outs during a 6-4 road loss against Detroit. 

Thirty-two year old righty Nick Pivetta (3-1 1.57 ERA) was a sneaky good free agent signing for the Padres. Through 23 innings of work, Pivetta has allowed just one home run and fanned 24 batters while posting a minuscule 0.83 WHIP.

The Detroit Tigers have won nine of their first 11 home games and are clinging to a half-game lead over Cleveland for the top spot in the AL Central Division. On Monday, 2B Gleyber Torres went 3-for-5 with two RBIs and a run scored to spark the Detroit offense. OF Zach McKinstry collected three hits and scored a run for the Tigers, who improved to 14-9 overall.

Twenty-nine year old righty Jake Flaherty (1-1 2.53 ERA) is one of four Detroit starting pitchers with a sub 3.00 ERA. Through 21 plus innings, Flaherty has allowed just two long balls and struck out 25 batters while posting a sparkling 1.08 WHIP.

San Diego SP Yu Darvish (elbow) threw a bullpen session over the weekend and is expected to rejoin the rotation next month. Through 23 games, San Diego ranks 4th in OPS and 14th in runs scored. For the regular season, Detroit ranks 15th in OPS and 10th in runs scored. Take the under. Final Score Prediction, Detroit Tigers win 4-2.