Padres vs Tigers Picks and Prediction – 4/21/2025

FS1 will feature a Monday night MLB interleague battle between the San Diego Padres and the Detroit Tigers from Comerica Park. Be ready for the baseball season with all of our MLB predictions. The Padres (16-6) rank second in the majors with a 2.77 ERA and hold a half-game lead over Los Angeles for first place in the NL West Division. Last night, OF Fernando Tatis homered and scored three runs to spark San Diego to a 3-2 road victory against Houston.

Twenty-six year old righty Randy Vasquez (1-1 1.74 ERA) will head to the hill for the Padres in this contest. Through 20 plus innings, Vasquez sports an alarming 8:14 strikeout-to-walk-ratio.

The Detroit Tigers have won eight of their first ten home games and own a half-game lead over Cleveland for the top spot in the AL Central Division. On Sunday, Kansas City batters went 3-for-13 with runners in scoring position and left ten men on base during a 4-3 home loss versus Kansas City. OF Zach McKinstry collected three hits and drove in a pair of runs for the Tigers, who fell to 13-9 overall. 

Twenty-nine year old righty Jake Flaherty (1-1 2.53 ERA) is one of four Detroit starting pitchers with a sub 3.00 ERA. Through 21 plus innings, Flaherty has allowed just two long balls and struck out 25 batters while posting a sparkling 1.08 WHIP.

San Diego SP Yu Darvish (elbow) threw a bullpen session over the weekend and is expected to rejoin the rotation next month. Through 22 games, San Diego ranks 4th in OPS and 12th in runs scored. For the regular season, Detroit ranks 12th in OPS and 10th in runs scored. Take the Tigers to win at home. Final Score Prediction, Detroit Tigers win 6-3.