Padres vs Tigers Picks and Prediction – 4/23/2025

The San Diego Padres conclude a three-game series on the road Wednesday versus the Detroit Tigers. San Diego is 16-7 following its 6-4 loss to Detroit in the series opener on Monday. San Diego has lost four of the last six after opening the season by winning 14 of its first 17. San Diego fell into a first-place tie with the Los Angeles Dodgers at the top of the National League West following Monday's loss. Keep up to date with all the MLB action with our MLB previews.

Fernando Tatis Jr is batting .349 with eight home runs, 17 RBI, 30 hits, and an on-base percentage of .424 to lead San Diego in the five categories. Jackson Merrill, Gavin Sheets, and Luis Arraez each have three home runs, which is second to Tatis Jr. On Wednesday, the San Diego Padres will send Kyle Hart to the mound. The left-hander is 2-1 with a 6.48 ERA, 10 Ks, and 5 BBs.

The Detroit Tigers improved to 14-9 following Monday’s two-run win over the Padres. Gleyber Torres and Zach McKinstry each collected three hits in Monday's victory. Detroit has won four of the last five, and the Tigers hold a half-game lead over the second-place Cleveland Guardians and are five games ahead of the third-place Kansas City Royals.

Kerry Carpenter is batting .315 to lead Detroit, and Zach McKinstry is the leader in on-base percentage at .424. Spencer Torkelson is leading in home runs with seven, RBI with 21, and hits with 24. Detroit is batting .250 with a .389 slugging percentage. On Wednesday, Detroit will send Reese Olson to the mound. The right-hander is 2-1 with a 4.50 ERA, 18 Ks, and 10 BBs.

The Tigers will continue their strong start with a win at home on Wednesday. Detroit has won four of the last five, seven of the last 10 at home versus San Diego, and 9 of the last 11 at home overall. San Diego starter Kyle Hart is coming off a very poor outing in which the left-hander allowed five runs on 10 hits across five innings. Detroit starter Reese Olson is coming off a strong effort in which the right-hander allowed no runs on four hits across five innings. Final Score Prediction: Detroit Tigers win 7-3.