Padres vs Rockies Picks and Prediction – 5/11/2025

By: Ricky MacKenzie |

Last Updated: 05/09/2025 at 10:30 PM ET

San Diego Padres at Colorado Rockies 05/10/25 - MLB Picks & Predictions
Game Start: 5/11/2025, 12:10 AM UTC
Latest Odds: SDP -200 ; O/U 11.5

Padres vs Rockies Prediction

This Saturday, Stephen Kolek and the San Diego Padres head to Coors Field to take on Bradley Blalock and the Colorado Rockies in a lopsided National League West matchup. Get our free MLB Picks all season long! The Padres, now 23-13, are coming off a narrow 4-3 loss to the Yankees and will look to rebound against the struggling Rockies.

Kolek will be making his first start of the season and will need to stay composed in the hitter-friendly environment of Coors Field. San Diego’s offense, led by a balanced and productive core, should provide plenty of support if Kolek can keep the ball down and limit early damage.

The Rockies, sitting at 6-31, continue to spiral after an 11-1 blowout loss to the Tigers on Thursday. Blalock also gets his first start and faces a tough task against a lineup that thrives on mistake pitches. Colorado has struggled in all phases and has shown little consistency at the plate or on the mound.

Key to the game will be how both rookie pitchers handle pressure. San Diego’s experience and ability to capitalize on mistakes give them a major advantage. If they strike early, it could be another long night for Colorado’s pitching staff.

Padres vs Rockies Pick Analysis

San Diego’s lineup depth, Colorado’s pitching woes, and a clear talent gap should make this a comfortable road win for the Padres. Kolek will be tested, but San Diego’s offense should handle the rest. Take the Padres to dominate this game from start until finish. Final Score Prediction, San Diego Padres win 7-3.

Our Free MLB Pick for Colorado Rockies vs San Diego Padres

San Diego Padres -1.5