Padres vs Reds Picks and Prediction – 6/28/2025

The San Diego Padres play the second game of a three-game series on the road Saturday versus the Cincinnati Reds. The Padres improved to 44-36 following a 1-0 victory over the Washington Nationals on Wednesday. Nick Pivetta struck out 10 in 7 innings for the Padres. San Diego has won four of the last five but trails first-place Los Angeles in the National League West by six games. Keep up to date with all the MLB action with our MLB picks.

Manny Machado is batting .298 with 47 RBI, 91 hits, and an on-base percentage of .360 to lead San Diego in the four categories. Fernando Tatis Jr leads in home runs with 15. San Diego is batting .248 with a .379 slugging percentage. On Saturday, the San Diego Padres will send Randy Vasquez to the mound. The right-hander is 3-4 with a 3.60 ERA, 45 Ks, and 37 BBs.

The Cincinnati Reds are 42-39 following a 7-1 loss to the New York Yankees on Wednesday, snapping a three-game winning streak by the Reds. Cincinnati’s Elly De La Cruz had two hits in the loss. Brady Singer suffered the loss after allowing four runs on six hits across five innings. Cincinnati trails first-place Chicago in the National League Central by six games. 

TJ Friedl is batting .283 to lead Cincinnati and has a team high on-base percentage of .372. Elly De La Cruz is the leader in home runs with 18, RBI with 55, and hits with 86. Cincinnati is batting .247 with a .401 slugging percentage. On Saturday, the Cincinnati Reds will send Andrew Abbott to the mound. The left-hander is 7-1 with a 1.79 ERA, 72 Ks, and 20 BBs.

Cincinnati has won 12 of its last 18, and the Reds have won four of the last six versus an opponent from the National League. San Diego has performed well of late, but the Padres have lost five of the last seven when playing on the road. Cincinnati starter Andrew Abbott has performed well in each of the last three outings, allowing two runs on 15 hits across 21.2 innings. Final Score Prediction: Cincinnati Reds win 5-2.

• Cincinnati is 12-6 in its last 18
• The UNDER has cashed in 5 of the Reds’ last 6