Padres vs Reds Picks and Prediction – 6/27/2025

The San Diego Padres open a three-game series on the road Friday versus the Cincinnati Reds. The Padres improved to 44-36 following Wednesday’s 1-0 victory over the Washington Nationals. Nick Pivetta struck out 10 in 7 innings for the Padres. San Diego has won four of the last five but trails first-place Los Angeles in the National League West by 5 ½ games. Keep up to date with all the MLB action with our expert MLB picks.

Manny Machado is batting .298 with 47 RBI, 91 hits, and an on-base percentage of .360 to lead San Diego in the four categories. Fernando Tatis Jr leads in home runs with 15. San Diego is batting .248 with a .379 slugging percentage. On Friday, San Diego will send Dylan Cease to the mound. The right-hander is 3-6 with a 4.43 ERA, 109 Ks, and 33 BBs.

The Cincinnati Reds dropped to 42-39 following Wednesday’s 7-1 loss to the New York Yankees, snapping a three-game winning streak by the Reds. Cincinnati’s Elly De La Cruz had two hits in the loss. Brady Singer suffered the loss after allowing four runs on six hits across five innings. Cincinnati trails first-place Chicago in the National League Central by 5 ½ games 

TJ Friedl is batting .283 to lead Cincinnati and has a team high on-base percentage of .372. Elly De La Cruz is the leader in home runs with 18, RBI with 55, and hits with 86. Cincinnati is batting .247 with a .401 slugging percentage. On Friday, Cincinnati will send Nick Martinez to the mound. The right-hander is 4-8 with a 4.40 ERA, 63 Ks, and 19 BBs.

Cincinnati will win at home on Friday when hosting San Diego, but the play here is UNDER. The UNDER has cashed in four of San Diego's last five and five of Cincinnati's last six. San Diego starter Dylan Cease pitched well last time out, allowing one run on three hits across 6.2 innings. Cincinnati starter Nick Martinez has had two consecutive strong outings, allowing no runs on no hits across three innings, with both appearances out of the bullpen. Final Score Prediction: Cincinnati Reds win but our best play is UNDER 4-2.