Padres vs Cubs Picks and Prediction – 4/4/2025

The San Diego Padres open a three-game series on the road Friday versus the Chicago Cubs. San Diego is 7-0 and second in the National League West, a half-game behind the Los Angeles Dodgers. San Diego defeated the Cleveland Guardians 5-2 on Wednesday to complete a three-game sweep of the series. The Padres have swept Atlanta and Cleveland to open the season. Keep up to date with all the MLB action with our MLB previews.

Fernando Tatis Jr is batting .423 with 11 hits and a .484 on-base percentage to lead San Diego in each of the three categories. Jackson Merrill is the leader in home runs with two and RBI with eight. San Diego has a team batting average of .298 and a slugging percentage of .440. On Friday, San Diego will send Randy Vasquez to the mound. The right-hander is 0-0 with a 0.00 ERA, 3 Ks, and 4 BBs.

The Chicago Cubs look for a fourth consecutive win on Friday when opening their series at home versus the San Diego Padres. Chicago is 5-4 and second in the National League Central, a half-game behind the St. Louis Cardinals. The Cubs defeated the Athletics 10-2 on Wednesday to complete a three-game sweep. Seiya Suzuki hit a pair of home runs and knocked in five runs for the Cubs.

Kyle Tucker is batting .324 with four home runs, 11 RBI, 12 hits, and a .444 on-base percentage to lead Chicago in each of the five categories. Seiya Suzuki also has four home runs and 11 RBI for the Cubs. Chicago has a team batting average of .255 and a slugging percentage. On Friday, Chicago will send Shota Imanaga to the mound. The left-hander is 1-0 with a 0.82 ERA, 6 Ks, and 6 BBs.

The play here is UNDER. The UNDER has cashed in four of San Diego's last five, eight of Chicago's last 11 versus San Diego and in seven of Chicago's last eight played at home. San Diego starter Randy Vasquez gave up no runs on four hits across six innings in a 1-0 win last Saturday. Chicago starter Shota Imanaga has allowed just one run across 11 innings. Final Score Prediction, Chicago Cubs win but our best play is UNDER 4-2.