Padres vs Diamondbacks Picks and Prediction – 6/15/2025

San Diego and Arizona wrap up this series at Chase Field on June 15 at 2:10 PM ET. Nick Pivetta (6-2, 3.48 ERA) goes for the Padres, while Merrill Kelly (6-2, 3.18 ERA) gets the nod for the Diamondbacks. San Diego dropped the opener 5-1 and now sits at 38-30, while Arizona, 35-34, is riding momentum after the win. Elevate your MLB game with our top-notch MLB picks.

San Diego's offense continues to be inconsistent, dropping three of its last four, including Thursday’s 5-1 loss to the Diamondbacks. The Padres had a solid showing in an 11-1 win over the Dodgers earlier in the week but followed that with flat efforts in back-to-back games. They need more from the top of the lineup, especially against a rising divisional opponent.

On the mound, San Diego still ranks among the better staffs in MLB with a 3.46 ERA and 1.22 WHIP. Nick Pivetta has been solid, punching out 79 in 72.1 innings with just eight homers allowed. Injuries continue to pile up though, with Yu Darvish and Michael King on the IL, thinning the rotation. Offensively, Manny Machado leads with a .319 average and 39 RBIs, and Fernando Tatis Jr. has chipped in 13 homers. The team is hitting .246 with a .314 OBP and has gone just 17-18 on the road.

Arizona has turned a corner lately, winning four straight and showing some serious power in the process. Friday's 5-1 win over San Diego featured a solid outing from the bullpen and enough timely hitting. The Diamondbacks scored 28 runs in a three-game sweep of Seattle before the Padres came to town.

The pitching is still a concern overall with a 4.70 ERA, but Merrill Kelly is the ace of this staff and gives them a legit shot every five days. He has posted a 0.99 WHIP and matched Pivetta with 79 Ks, but in 10 more innings. Offensively, Arizona has muscle—100 home runs as a team, third in MLB. Corbin Carroll has blasted 20 of those, and Eugenio Suarez leads with 52 RBIs. The team’s .255 average and .332 OBP have powered a 19-17 record at home.

Arizona is hot right now and has scored 46 runs over the last five games. Kelly has been more efficient than Pivetta, and he’s got more support behind him—Arizona leads San Diego in batting average, OBP, slugging, runs, and home runs. The Padres have dropped four of the last five, and the rotation is beat up. Arizona wins again behind their bats and Kelly. Final Score Prediction: Arizona Diamondbacks wins 6-3.