Athletics vs Giants Picks and Prediction – 5/17/2025

This Friday, JP Sears and the Athletics head to Oracle Park to take on Logan Webb and the San Francisco Giants in a Bay Area rivalry matchup. Get our free MLB Picks all season long! The Athletics, now 22-21, are coming off a 9-3 loss to the Dodgers on Wednesday and will look to bounce back with stronger pitching and cleaner execution.

Sears has been one of the Athletics’ more dependable arms, mixing speeds well and attacking the strike zone. He’ll be tested by a Giants lineup that has shown increased power and late-game resilience. Limiting free passes and avoiding big innings will be critical for Sears to keep his club in it.

The Giants, now 25-19, dropped a wild 8-7 game to the Diamondbacks on Wednesday but continue to trend upward overall. Webb takes the mound as their ace, bringing excellent command, ground ball efficiency, and the ability to control the tempo of a game. He’ll look to neutralize an Athletics lineup that’s been inconsistent.

This game could come down to which starter settles in quicker and whose bullpen holds up late. The Athletics will need to scratch out early runs and give Sears some breathing room, while the Giants aim to strike early and let Webb take over.

With Webb on the mound and the Giants playing at home, San Francisco holds the edge. Sears will battle, but the Giants’ lineup and overall depth should lead them to a bounce-back win. Take the Giants to win this one and to cover the run line. Final Score Prediction, San Francisco Giants win 5-3.