Athletics vs Astros Picks and Prediction – 5/28/2025

The Athletics play the second game of a three-game series on the road Wednesday versus the Houston Astros. The Athletics are 23-31 following a 5-4 victory over the Philadelphia Phillies on Sunday. Willie MacIver snapped a tie with an RBI single in the eighth inning in the win. The Athletics snapped an 11-game losing streak with the win on Sunday. Keep up to date with all the MLB action with our expert MLB picks.

Jacob Wilson is batting .350 to lead the Athletics and has team highs in hits with 70 and on-base percentage at .393. Brent Rooker is the leader in home runs with 12, and Tyler Soderstrom is the leader in RBI with 31. The Athletics are batting .256 with a .419 slugging percentage. On Wednesday, the Athletics will send Luis Severino to the mound. The right-hander is 1-4 with a 4.11 ERA, 50 Ks, and 20 BBs.

The Houston Astros improved to 26-25 following a 5-3 victory over the Seattle Mariners on Sunday. Christian Walker hit a walkoff two-run homer in the bottom of the 9th inning for the Astros. Houston won three out of four over the American League West first-place Mariners. The Astros have won five of the last eight and moved within 1 ½ games of Seattle. 

Jake Myers is batting .300 to lead Houston, and Jeremy Pena has a team-high of 59 hits. Isaac Paredes is the leader in home runs with 11, RBI with 31, and on-base percentage at .377. Houston is batting .254 with a .386 slugging percentage. On Wednesday. Houston will send Lance McCullers Jr to the mound. The right-hander is 0-1 with a 6.57 ERA, 14 Ks, and 10 BBs.

Houston will win at home on Wednesday when hosting the Athletics, but the play here is UNDER. The UNDER has cashed in seven of Houston's last nine and five of Houston's last six played at home. Athletics starter Luis Severino has had two consecutive solid outings, allowing two runs on 11 hits across 12 innings. Houston starter Lance McCullers Jr has had two consecutive solid outings, allowing two runs on nine hits across 8.1 innings. Final Score Prediction: Houston Astros win but our best play is UNDER 4-2.