Athletics vs Guardians Picks and Prediction – 7/20/2025

The Athletics complete a three-game series on the road Saturday versus the Cleveland Guardians. The Athletics are 41-58 following an 8-6 loss to Cleveland on Friday in the opening game of the series. The loss snapped a two-game winning streak for the Athletics. The A’s trail first-place Houston in the American League West by 16 games. Keep up to date with all the MLB action with our expert MLB picks.

Jacob Wilson is batting .326 with 112 hits and an on-base percentage of .369 to lead the Athletics in each of the three categories. Brent Rooker leads in home runs with 21, and Tyler Soderstrom leads in RBI with 56. The Athletics are batting .249 with a .419 slugging percentage. On Sunday, the A’s will send Jeffrey Springs to the mound. The left-hander is 8-6 with a 3.93 ERA, 86 Ks, and 38 Ks.

The Cleveland Guardians are 47-49 following Friday’s two-run victory over the Athletics. Jonathan Rodriguez hit his first MLB home run, and Slade Cecconi pitched 8.1 innings to set a new personal record for innings pitched in one game. The Guardians have won three straight and seven of the last eight. Cleveland trails first-place Detroit in the American League Central by 11 games.

Jose Ramirez is batting .298 with 18 home runs, 50 RBI, 104 hits, and an on-base percentage of .363 to lead Cleveland in each of the five categories. Cleveland is batting .222 with a .366 slugging percentage. On Sunday, the Cleveland Guardians will send Gavin Williams to the mound. The right-hander is 5-4 with a 3.70 ERA, 95 Ks, and 57 BBs.

The Athletics will win on the road Sunday when visiting Cleveland, but the play here is OVER. The OVER has cashed in six of Cleveland's last nine and four of the Athletics’ last five played on the road. Athletics starter Jeffrey Springs has allowed eight runs across the last 30 innings, with the A’s winning four of the five during that stretch. Cleveland starter Gavin Williams allowed three runs on four hits across five innings last time out. Final Score Prediction: Athletics win but our best play is OVER 7-5.