Athletics vs White Sox Picks and Prediction – 4/16/2025

The Athletics (6-10) head to Chicago to face the White Sox (4-11) on April 16 at 5:40 PM EST. Both clubs are looking to bounce back from recent struggles, with the A’s coming off an 8-0 loss to the Mets, while the Sox dropped a 3-1 game to the Red Sox. Osvaldo Bido (1-1, 3.00 ERA) will take the mound for the Athletics, matched up against Jonathan Cannon (0-2, 5.79 ERA) for Chicago. Elevate your MLB game with our top-notch MLB picks.

The Athletics continue to show flashes of potential despite inconsistency. They dropped three of the last five, including a shutout loss to New York, but also put up a strong 10-run performance earlier against San Diego. The A's offense is led by Tyler Soderstrom, who’s mashing with a .305 average, 6 home runs, and 11 RBIs. Jacob Wilson has been another bright spot, slashing .344/.344/.508 and helping the lineup stay afloat.

The Athletics’ issues lie in pitching depth. While Bido has held his own with a 3.00 ERA and 14 strikeouts across 15 innings, the team’s overall ERA sits at 4.91 with a bloated 1.54 WHIP. Opponents are hitting .269 against the A’s, and they’ve allowed 147 Ks but also handed out 68 walks. Injuries to Zack Gelof and Ken Waldichuk continue to thin out key areas, putting extra weight on Bido’s performance.

Chicago hasn’t been able to generate much momentum and comes into this one having lost three of the last five, including a quiet showing in Sunday’s loss to Boston. They put together a strong 11-1 win in the middle of the series, but that offensive explosion has been rare. Andrew Benintendi had been the top power option with 2 homers and 6 RBIs before hitting the IL, and Brooks Baldwin is stepping up with a .268 average and 7 RBIs.

On the mound, the White Sox have fared decently, ranking better than Oakland with a 3.55 ERA and 1.28 WHIP. Still, Cannon has struggled with control—giving up 9 walks and 3 homers in 14 innings—and that’s a problem against an A’s lineup that can capitalize on mistakes. Injuries continue to mount for Chicago, with Benintendi, Tauchman, Lee, Rojas, and others all sidelined.

The Athletics lineup has more firepower right now with Soderstrom and Wilson hitting the ball well, and Bido has been more reliable than Cannon on the mound. Chicago’s injuries and offensive inefficiency—they're hitting just .201 as a team—give the A’s the edge despite their flaws. Final Score Prediction: Athletics win 5-3.