Pirates vs Brewers Picks and Prediction – 6/25/2025

NL Central Division foes will square off on Wednesday afternoon, when the Pittsburgh Pirates and the Milwaukee Brewers wrap up their series from American Family Field. Be ready for the baseball season with all of our MLB predictions. The Pirates (32-49) have dropped 28 of their first 40 road games and are stuck in last place. Last night, Pittsburgh 2B Nick Gonazales hit a three-run blast during a 9-3 road loss. 

NL Rookie of the Year Paul Skenes (4-6 1.85 ERA) is making a strong case to become the NL Cy Young Award winner. Through 102 innings of work, Skenes has struck out 106 batters and ranks second in the majors with a 0.88 WHIP.

The Milwaukee Brewers have won eight of their last 11 games and trail first place Chicago by three games. During Tuesday’s home victory, SS Joey Ortiz homered twice and 3B Caleb Durbin added a three-run shot to power the Milwaukee offense. SP Freddy Peralta (8-4) allowed three runs in five innings to earn the win for the Brewers (44-36), who improved to 24-16 at home. 

Rookie right-hander Jacob Misiorowski (2-0 1.64 ERA) will make his third career major league start for the Brewers. Through his first 11 innings, Misiorowski has allowed just one hit and has retired 11 batters by strikes. 

Milwaukee SP Brandon Woodruff (shoulder) threw a 60-pitch simulated game on Monday and is expected to begin a rehab assignment. Through 81 games, Pittsburgh ranks 29th in OPS and 30th in runs scored. For the season, Milwaukee ranks 20th in OPS and 10th in runs scored. Take the Pirates to win on the road. Final Score Prediction, Pittsburgh Pirates win 4-2.