Pirates vs Reds Picks and Prediction – 4/11/2025

The Pittsburgh Pirates open a three-game series on the road Friday versus the Cincinnati Reds. Pittsburgh is 5-8 following a 2-1 victory over the St. Louis Cardinals on Wednesday. Pittsburgh’s Joey Bart singled in the winning run for the Pirates in the 13th inning. Pittsburgh has won three of the last four but trails first in the National League Central by three games. Keep up to date with all the MLB action with our MLB picks.

Isiah Kiner-Falefa is batting .300 with 12 hits and an on-base percentage of .391 to lead Pittsburgh in each of the three categories. Oneil Cruz is the leader in home runs with two, and Bryan Reynolds is the leader in RBI with six. Pittsburgh has a team batting average of .198 and a slugging percentage of .301. On Friday, Pittsburgh will send Bailey Falter to the mound. The left-hander is 0-1 with an 8.10 ERA, 9 Ks, and 1 BBs. 

The Cincinnati Reds look to bounce back from a loss on Wednesday with a victory on Friday when opening their series at home versus Pittsburgh. Cincinnati is 5-8 and tied for last in the National League Central with Pittsburgh. The Reds lost 8-6 to San Francisco on Wednesday, giving up a walk-off home run to the Giants and snapping a two-game winning streak. 

Elly De La Cruz is batting .250 with 12 RBI and 13 hits to lead Cincinnati in each of the three categories. Matt McLain is the leader in home runs with three, and Gavin Lux leads in on-base percentage at .306. Cincinnati is batting .206 with a slugging percentage of .329. On Friday, Cincinnati will send Brady Singer to the mound. The right-hander is 2-0 with a 2.25 ERA, 15 Ks, and 3 BBs.

Pittsburgh has lost four of its last six and will face a strong starter on the mound for the Reds on Friday. Pittsburgh starter Bailey Falter was hit hard last time out, allowing seven runs on seven hits across just four innings, including serving up a pair of home runs. Cincinnati starter Brady Singer is off to a strong start, allowing three runs across 12 innings. Final Score Prediction, Cincinnati Reds win 5-2.