Phillies vs Mets Picks and Prediction – 4/21/2025

By: David Anicetti |

Last Updated: 04/20/2025 at 8:32 PM ET

Philadelphia Phillies at New York Mets 04/21/25 - MLB Picks & Predictions
Game Start: 4/21/2025, 11:10 PM UTC
Latest Odds: NYM -120 ; O/U 8

Phillies vs Mets Prediction

On Monday, the Philadelphia Phillies open a three-game series on the road in the Big Apple versus the New York Mets. Philadelphia is 13-8 following its 11-10 victory over the Miami Marlins on Saturday. Trea Turner collected four hits while two others had three hits apiece in the victory for the Phillies. Philadelphia is second in the National League East, one game behind the first-place Mets. Keep up to date with all the MLB action with our expert MLB picks.

Nick Castellanos is batting .307 with 23 hits to lead Philadelphia in both categories. Kyle Schwarber is the leader in home runs with seven, RBI with 16, and on-base percentage with .436. Philadelphia is batting .253 with a .399 slugging percentage. On Monday, the Philadelphia Phillies will send Aaron Nola to the mound. The right-hander is 0-4 with a 6.65 ERA, 25 Ks, and 9 BBs.

The New York Mets improved to 14-7 following Saturday’s 3-0 victory over the St Louis Cardinals. Kodai Senga extended his scoreless innings streak to 19. Pete Alonso hit a home run as the Mets won for the third consecutive time and have won five of the seven. New York leads Philadelphia by one game at the top of the NL East and is 5 ½ games ahead of third-place Miami.

Pete Alonso is batting .356 with six home runs, 23 RBI, 26 hits, and an on-base percentage of .467 to lead New York in each of the five categories. Brandon Nimmo is second in both home runs with four and RBI with nine. New York is batting .225 with a .389 slugging percentage. On Monday, the New York Mets will send Tylor Megill to the mound. The right-hander is 2-2 with a 1.40 ERA, 20 Ks, and 7 BBs.

Phillies vs Mets Pick Analysis

New York has won 12 of its last 16, and the Mets have won nine of the last 10 played at home. Philadelphia starter Aaron Nola is off to a poor beginning to the season with a 6.65 ERA. The right-hander is coming off his worst start, after allowing six runs on nine hits across 5.1 innings. New York starter Tylor Megill has allowed just three earned runs across 19.1 innings in four outings. Final Score Prediction: New York Mets win 6-2.

Our Free MLB Pick for New York Mets vs Philadelphia Phillies

New York Mets -120