Phillies vs Astros Picks and Prediction – 6/26/2025

Daikin Park will play host to a Thursday afternoon MLB interleague battle between the Philadelphia Phillies and the Houston Astros. Be ready for the baseball season with all of our MLB predictions. The Phillies (47-33) have dropped the first two games of this series and are clinging to a half-game lead over New York for the top spot in the NL East Division. Last night, Philadelphia batters struck out ten times and left seven men on base during a 2-0 road loss against Houston. 

Twenty-eight year old southpaw Cristopher Sanchez (6-2 2.87 ERA) is quietly pitching well for the Phillies. Through 87 plus innings, Sanchez has retired 92 batters by strikes and owns a solid 1.19 WHIP.

The Houston Astros have won seven of their last ten games and hold a 5.5 game lead over Seattle for first place in the AL West Division. During Wednesday’s home victory. Isaac Paredes had an RBI single and Victor Caratini added a solo shot to provide the Houston offense. Josh Hader nailed down his 21st save for the Astros (47-33), who improved to 29-13 at home. 

Twenty-six year old righty Hunter Brown (8-3 1,88 ERA) is a lock to make his first All-Star Game appearance. Through 91 innings of work, Brown has fanned 109 batters and ranks sixth in the majors with a 0.92 WHIP.

Philadelphia 1B Bryce Harper (wrist) went through his usual pre-game routine on Tuesday and could be activated for this game. Through 80 games, Philadelphia ranks 9th in OPS and 11th in runs scored. For the season, Houston ranks 15th in OPS and 19th in runs scored. Take the Astros to win at home. Final Score Prediction, Houston Astros win 5-2.