Phillies vs Astros Picks and Prediction – 6/25/2025

The Philadelphia Phillies (47–31) travel to face division-leading Houston Astros (45–33) under the lights at Daikin Park. This AL–NL clash pits two hot teams in a crucial midweek showdown. The Astros have the edge on paper, but Philadelphia’s recent form and strong pitching staff make this one to watch. Get in on the action with our free MLB picks.

Ranger Suárez (6–1, 2.20 ERA, 1.06 WHIP) toes the rubber for Philadelphia, riding one of baseball's best early-season performances. In his last outing, he threw seven shutout innings, permitting only two hits while striking out eight. The Phillies arrive with momentum, winning nine of their last eleven and going 4–2 against Houston recently. Offensively, Philly averages 4.7 runs per game (7th in MLB) and boasts potent bats led by Kyle Schwarber, even without Bryce Harper, who remains on the IL.

Houston counters with Framber Valdez (8–4, 3.09 ERA), an AL West ace who has won eight of his last ten starts, striking out 99 in 15 outings. The Astros are blazing hot—with a 9–3 run in their past 12 games and undefeated in their last five at home. Offensively, Jeremy Peña (.326 avg, 11 HR) and Isaac Paredes (16 HR, 45 RBI) provide pop, though injuries have thinned their depth, putting added stress on the rotation.

This is shaping up to be a classic pitching duel with two elite left-handers on the mound. Suárez’s dominance and Philly’s road form give the Phillies a legitimate shot, while the Astros’ momentum and offensive firepower can't be ignored. With Harper on the IL, the offensive pendulum swings to Houston and we think the Astros win 3-2.