Phillies vs Guardians Picks and Prediction – 5/11/2025

The Philadelphia Phillies (23–16) and Cleveland Guardians (23–16) are set to conclude their three-game interleague series on Sunday night at Progressive Field. First pitch is scheduled for 7:10 PM ET, with national coverage on ESPN. The series is tied 1–1, with both teams looking to secure the series win. Get in on the action with our free MLB picks.

The Phillies have been performing well offensively, averaging over 4 runs per game with a team batting average of .257. Kyle Schwarber leads the team with 12 home runs and 29 RBIs, while Trea Turner boasts a .318 batting average. On the mound, Zack Wheeler (3–1, 3.35 ERA) will start for Philadelphia. Wheeler has been effective this season, recording 66 strikeouts over 51 innings with a WHIP of 0.94. In his last start against the Tampa Bay Rays, Wheeler pitched seven innings, allowing two runs and striking out nine. 

The Guardians have a strong home record at 12–6 and are averaging 4.2 runs per game. Steven Kwan leads the team with a .327 batting average, while Kyle Manzardo has contributed nine home runs and 22 RBIs. Luis Ortiz (2–3, 5.30 ERA) will take the mound for Cleveland. Ortiz has had mixed results this season, with his last outing against the Washington Nationals resulting in five earned runs over 5.1 innings. However, Ortiz has a history of success against the Phillies, having not allowed a run in eight innings across two appearances in 2024.

With both teams evenly matched in the series, the finale promises to be competitive. The Phillies have the edge in starting pitching with Wheeler's consistent performance, and an opportunity to play out in front. The starting pitching edge is most likely enough here as the Phillies win this one by a score of 5-3.