Phillies vs Guardians Picks and Prediction – 5/10/2025

By: David Anicetti |

Last Updated: 05/09/2025 at 9:13 PM ET

Philadelphia Phillies at Cleveland Guardians 05/10/25 - MLB Picks & Predictions
Game Start: 5/10/2025, 10:10 PM UTC
Latest Odds: PHI -125 ; O/U 7.5

Phillies vs Guardians Prediction

The Philadelphia Phillies play the second game of a three-game series on the road Saturday versus the Cleveland Guardians. Philadelphia improved to 22-15 following its 7-6 victory over the Tampa Bay Rays on Thursday. Philadelphia has won three straight and five of the last six. Philadelphia trails first-place New York by 1 ½ games in the National League East. Keep up to date with all the MLB action with our expert MLB picks.

Trea Turner is batting .310 with 44 hits to lead Philadelphia in both categories. Kyle Schwarber is the leader in home runs with 12, RBI with 28, and on-base percentage at .406. Philadelphia is batting .258 with a .406 slugging percentage. On Saturday, Philadelphia will send Ranger Suarez to the mound. The left-hander is 0-0 with a 17.18 ERA, 6 Ks, and 2 BBs.

The Cleveland Guardians are 22-15 following Wednesday’s 8-6 victory over the Washington Nationals. Carlos Santana had a bases-loaded double to drive in three runs when Cleveland scored eight runs in the sixth inning. Cleveland was off on Thursday. The Guardians have won two straight and four in the last five. Cleveland is second in the American League Central, 2 ½ games behind the first-place Detroit Tigers.

Steven Kwan is batting .333 with 49 hits and a .391 on-base percentage to lead Cleveland in the three categories. Kyle Manzardo is the leader in home runs with eight and RBI with 21. Cleveland is batting .238 with a .386 slugging percentage. On Saturday, the Cleveland Guardians will send Tanner Bibee to the mound. The right-hander is 3-2 with a 4.26 ERA, 28 Ks, and 16 BBs.

Phillies vs Guardians Pick Analysis

Cleveland has won four of its last five, and the Guardians are 11-5 over the last 16 played at home. In just one appearance this season, Philadelphia starter Ranger Suarez was hit hard, allowing seven runs on seven hits across 3.2 innings. Cleveland starter Tanner Bibee has had three consecutive strong outings, allowing five runs on 15 hits across 18 innings. Final Score Prediction: Cleveland Guardians win 5-2.

Our Free MLB Pick for Cleveland Guardians vs Philadelphia Phillies

Cleveland Guardians +105