Phillies vs Cubs Picks and Prediction – 4/27/2025

This Sunday, Aaron Nola and the Philadelphia Phillies take on Jameson Taillon and the Chicago Cubs at Wrigley Field, wrapping up their weekend series. Get our free MLB Picks

all season long! The Phillies, now 14-13, are coming off a dominant 10-4 win over the Cubs on Saturday, with their offense showing signs of heating up after a slow start.

Nola has been strong early in the season, mixing his pitches effectively and avoiding big innings. He’ll aim to build off recent success and attack a Cubs lineup that has been inconsistent over the past week. Philadelphia’s offense will look to stay aggressive and jump out early again.

The Cubs, who dropped Saturday’s game 10-4, will send Taillon to the mound hoping to salvage the series. Taillon has struggled with command at times and will need to keep the ball down against a Phillies lineup that feasts on mistakes. Chicago’s bats will also need to be more opportunistic with runners on base.

Key to this matchup will be how well Taillon manages traffic early, while Nola focuses on putting up zeros and getting deep into the game. The Phillies will want to stay disciplined at the plate, while the Cubs must find a way to slow down Philadelphia’s top of the order.

With Nola dealing and Philadelphia’s bats finding rhythm, the Phillies should have the upper hand again. Taillon will battle, but unless Chicago’s offense responds in a big way, another loss could be looming. Take the Phillies to win the game and to keep things rolling. Final Score Prediction, Philadelphia Phillies win 6-3.