Phillies vs Cubs Picks and Prediction – 4/26/2025

By: David Anicetti |

Last Updated: 04/25/2025 at 9:27 PM ET

Philadelphia Phillies at Chicago Cubs 04/26/25 - MLB Picks & Predictions
Game Start: 4/26/2025, 8:05 PM UTC
Latest Odds: CHC -110 ; O/U 8

Phillies vs Cubs Prediction

The Philadelphia Phillies play the second game of a three-game series on the road Saturday versus the Chicago Cubs. Philadelphia is 13-12 following its 4-3 loss to the New York Mets on Wednesday. Philadelphia was swept in its three-game series with New York, and the Phillies have lost each of the last four. Philadelphia is second in the National League East, five games behind the first-place Mets. Keep up to date with all the MLB action with our MLB previews.

Bryson Stott is batting .298 to lead Philadelphia, and Nick Castellanos is the leader in hits with 25. Kyle Schwarber is the leader in home runs with seven, RBI with 16, and on-base percentage at .411. Philadelphia is batting .251 with a .381 slugging percentage. On Saturday, Philadelphia will send Jesus Luzardo to the mound. The left-hander is 2-0 with a 2.08 ERA, 36 Ks, and 7 BBs.

The Chicago Cubs improved to 16-10 following a 7-6 victory over the Los Angeles Dodgers on Wednesday night. Pete Crow-Armstrong homered and had four RBI in Chicago's victory. Chicago swept Los Angeles in a short two-game series after winning the opener 11-10. Chicago leads the National League Central by three games over the Milwaukee Brewers.

Kyle Tucker is batting .314 with seven home runs, 25 RBI, 32 hits, and an on-base percentage of. 423 to lead Chicago in the five categories. Seiya Suzuki is second in both home runs with six and RBI with 20. Chicago is batting .265 with a .460 slugging percentage. On Saturday, Chicago will send Ben Brown to the mound. The right-hander is 2-1 with a 4.57 ERA, 26 Ks, and 13 BBs.

Phillies vs Cubs Pick Analysis

Chicago has won four of the last five and is coming off a two-game sweep over the Los Angeles Dodgers. The Cubs have won five of the last seven versus an opponent from the National League. Philadelphia was swept in its most recent series by the New York Mets and has lost four straight. Chicago starter Ben Brown has had two consecutive strong outings, allowing one run across 10 innings. Final Score Prediction: Chicago Cubs win 5-3.

Our Free MLB Pick for Chicago Cubs vs Philadelphia Phillies

Chicago Cubs -110