Yankees vs Blue Jays Picks and Prediction – 7/22/2025

By: David Anicetti |

Last Updated: 07/21/2025 at 9:08 PM ET

New York Yankees at Toronto Blue Jays 07/22/25 - MLB Picks & Predictions
Game Start: 7/22/2025, 11:07 PM UTC
Latest Odds: TOR -120 ; O/U 9

Yankees vs Blue Jays Prediction

The New York Yankees play the second game of a three-game series on the road Tuesday versus the Toronto Blue Jays. New York is 55-44 following Sunday’s 4-2 victory over the Atlanta Braves. Aaron Judge homered for the 36th time this season and is now tied for sixth place in Yankees history for home runs. New York trails first-place Toronto by three games in the American League East. Keep up to date with all the MLB action with our MLB picks.

Aaron Judge is batting .352 with 36 home runs, 82 RBI, 128 hits, and an on-base percentage of .458 to lead New York in each of the five categories. Trent Grisham and two others are tied for second in home runs with 17 each. New York is batting .256 with a .455 slugging percentage. On Tuesday, New York will send Cam Schlittler to the mound. The right-hander is 1-0 with a 5.06 ERA, 7 Ks, and 2 BBs.

The Toronto Blue Jays are 58-41 following Sunday’s 8-6 victory over the San Francisco Giants. Addison Barger hit a two-run home run, while George Springer and Vladimir Guerrero Jr each hit solo homers for the Blue Jays. The Blue Jays lead the Yankees by three games in the AL East, and are five games ahead of the third-place Boston Red Sox.

Alejandro Kirk is batting .306 to lead Toronto. George Springer leads in home runs with 17, while Bo Bichette leads in RBI with 55 and hits with 112. Vladimir Guerrero Jr leads in on-base percentage at .385. Toronto is batting .261 with a .409 slugging percentage. On Tuesday, Toronto will send Max Scherzer to the mound. The right-hander is 1-0 with a 4.70 ERA, 24 Ks, and 7 BBs. 

Yankees vs Blue Jays Pick Analysis

Toronto has won 14 of its last 17, and the Blue Jays are undefeated in their last 10 games played at home. New York has lost four of its last five head-to-head versus the Blue Jays. Toronto right-hander Max Scherzer struggled last time out, allowing three runs on five hits across six innings. New York starter Cam Schlittler has allowed three runs on four hits across 5.1 innings in one appearance. Final Score Prediction: Toronto Blue Jays win 5-2.

Our Free MLB Pick for Toronto Blue Jays vs New York Yankees

Toronto Blue Jays -120