Yankees vs Guardians Picks and Prediction – 4/21/2025

Progressive Field will play host to a Monday night MLB clash between the New York Yankees and the Cleveland Guardians. Be ready for the baseball season with all of our MLB predictions. The Yankees (14-8) have won seven of their previous ten games and hold a two-game lead over Toronto for the top spot in the AL East Division. On Sunday, Max Fried (4-0) allowed just two hits across seven plus frames to lead New York to a 4-0 road victory against Tampa Bay. 

Twenty-nine year old righty Clarke Schmidt (0-0 4.76 ERA) will take the mound for the Yankees in this matchup. In his first start of the year, Schmidt (5.2 IP) gave up four hits and three runs during a 4-3 home victory versus Kansas City.

The Cleveland Guardians have won five of their first six home games and are a half-game behind Detroit for first place in the AL Central Division. On Sunday, 1B Kyle Manzardo crushed a two-run blast and delivered a sacrifice fly in the tenth inning to lift Cleveland to a 5-4 road victory against Pittsburgh. OF Steven Kwan added a two-run shot for the Guardians, who improved to 12-9 overall.

The Guardians will counter with twenty-five year old righty Gavin Williams (1-1 4.58 ERA) on Monday. Last time out, Williams was tagged for five runs across six plus frames during a 9-1 road loss against Baltimore. 

New York 1B Ben Rice (elbow) was absent from Sunday’s lineup and is listed as day-to-day. Through 22 games, New York ranks 2nd in OPS and 2nd in runs scored. For the regular season, Cleveland ranks 13th in OPS and 22nd in runs scored. Take the over. Final Score Prediction, New York Yankees win 6-5.