Yankees vs Orioles Picks and Prediction – 4/28/2025

By: Eddie Kline |

Last Updated: 04/27/2025 at 9:19 PM ET

New York Yankees at Baltimore Orioles 04/28/25 - MLB Picks & Predictions
Game Start: 4/28/2025, 10:35 PM UTC
Latest Odds: NYY -121 ; O/U 9.5

Yankees vs Orioles Prediction

Beautiful Camden Yards will play host to a Monday night MLB clash between the New York Yankees and the Baltimore Orioles. Be ready for the baseball season with all of our MLB predictions. The Yankees (17-11) are a game above .500 on the road and hold a two-game lead over Boston for first place in the AL East Division. On Sunday, New York swept visiting Toronto in a doubleheader by a combined 16-3 score. All-Star OF Aaron Judge homered in the night cap and raised his average to .406. 

Twenty-five year old righty Will Warren (1-0 4.79 ERA) will head to the hill for the Yankees in this contest. Last time out, Warren (5 IP) gave up two runs and struck out five batters during a 3-2 road loss against Cleveland. 

The Baltimore Orioles rank last in the majors with a 5.28 ERA and are stuck in the AL East Division basement. On Sunday, Baltimore batters went 0-for-9 with runners in scoring position and left seven men on base during a 7-0 road loss against Detroit. SP Dean Kremer (2-4) gave up five runs in five plus innings and took the loss for the Orioles (10-17), who fell to 5-11 on the road. 

Thirty-five year old righty Tomoyuki Sugano (2-1 3.54 ERA) will make his sixth career major league start for the Orioles. Through 28 innings of work, Sugano has retired just nine batters by strikes and owns a solid 1.14 WHIP.

Yankees vs Orioles Pick Analysis

New York DH Giancarlo Stanton (elbow) took batting practice on the field on Tuesday and hopes to make his season debut later next month. Through 27 games, New York ranks 1st in OPS and 4th in runs scored. For the season, Baltimore ranks 20th in OPS and 1st in runs scored. Take the over. Final Score Prediction, New York Yankees win 7-5.

Our Free MLB Pick for Baltimore Orioles vs New York Yankees

OVER 9.5