Mets vs Yankees Picks and Prediction – 5/16/2025

Yankee Stadium will be rocking on Friday night, when the New York Mets and the New York Yankees resume their bitter rivalry. Be ready for the baseball season with all of our MLB predictions. The Mets have split their first 22 road games and hold a 2.5 game lead over Philadelphia for first place in the NL East Division. On Wednesday, New York SP Clay Holmes (5-2) was tagged for four runs in six innings during a 4-0 home loss against Pittsburgh. 

Twenty-nine year old righty Tylor Megill (3-3 3.10 ERA) has blossomed into a quality starting option for the Mets. Through 40 plus innings, Megill has struck out 52 batters and allowed just three home runs while posting a respectable 1.25 WHIP.

The New York Yankees are five games above .500 at home and are four games clear of their nearest competition in the AL East Division race. On Wednesday, AL MVP Aaron Judge crushed his major league leading 15th home run during a 3-2 road victory against Seattle. 1B Paul Goldschmidt added a game-tying solo shot in the seventh inning for the Yankees, who improved to 25-18 overall. 

For the Yankees to attain their lofty preseason goals, southpaw Carlos Rodon (4-3 3.29 ERA) will have to stay healthy. In his last start, Rodon (6 IP) gave up four runs and retired ten batters by strikes during an 11-7 road loss against the Athletics. 

New York OF Jose Siri (leg) has resumed baseball activities and hopes to return to the lineup early next month. Through 44 games, the Mets rank 5th in OPS and 9th in runs scored. For the season, the Yankees rank 1st in OPS and 1st in runs scored. Take the under. Final Score Prediction, New York Yankees win 4-3.