Twins vs Cardinals Picks and Prediction – 3/27/2025

On Thursday, the Minnesota Twins face off against the St. Louis Cardinals at Busch Stadium in St. Louis, Missouri on Opening Day. Keep up to date with all the MLB action, with our expert MLB picks.

St. Louis comes into this matchup having won three of their last five games at the end of last season. In the previous season, Paul Goldschmidt stood out as the top home-run hitter for the St. Louis Cardinals, hitting 22 homers. Hot on his heels was Alec Burleson, who racked up 21 home runs. Burleson also distinguished himself by leading the team in runs batted in, tallying 78 RBIs. Brendan Donovan led the Cardinals in batting average, hitting .278 for the season. As the season came to a close, the Cardinals showed impressive form in their final five games, averaging six runs per game. They are now eager to exceed expectations in the new season and make a notable impact this season. Over the entire season, the team averaged 4.1 runs per game.

Minnesota enters this game having lost four of their last five games at the end of last season. In the previous season, Carlos Santana was the top home run hitter for the Minnesota Twins, smashing 23 homers. Close behind him was Ryan Jeffers, who hit 21 home runs. Santana was also the team's leader in RBIs, driving in a total of 71 runs. When it came to batting averages, Willi Castro held the highest on the team, hitting .247 over the season. Towards the end of the season, the Twins faced challenges in defense, conceding an average of 6.6 runs over their final five games. Despite these struggles, the team is looking to turn things around and aim for a division win in the upcoming season. Overall, the Twins managed to score an average of 4.6 runs per game throughout the season.

With Paul Goldschmidt's departure, the Cardinals are projected to rank low in the standings and potentially miss the playoffs. However, they're determined to prove their doubters wrong. In a highly competitive NL Central, they're aiming to unexpectedly clinch the division. They kick off their season by hosting the Twins at Busch Stadium. Like the Cardinals, the Twins also missed the playoffs last year but are eager to claim a division title and more. Last season, Minnesota’s starting pitcher, Pablo Lopez, held a 15-10 record with a 4.08 ERA, while St. Louis will counter with Sonny Gray, who recorded a 13-9 record and a 3.84 ERA. Final Score Prediction, St. Louis Cardinals win 11-2.