Twins vs Guardians Picks and Prediction – 4/29/2025

The Tuesday MLB schedule will get started with a matchup between the Minnesota Twins and the Cleveland Guardians from Progressive Field. Be ready for the baseball season with all of our MLB predictions. The Twins (13-16) are riding a four-game winning streak and are currently in fourth place in the AL Central Division standings. Last night, C Ryan Jeffers homered and drove in three runs to lead Minnesota to an 11-1 road triumph against Cleveland. 

Twenty-nine year old righty Chris Paddack (0-3 6.45 ERA) has scuffled through his first five starts for the Twins. Control has been an issue for Paddack, who has walked 13 batters and surrendered five long balls across 22 plus frames. 

The Cleveland Guardians have won eight of their first 13 home games and trail AL Central Division leading Detroit by three games. On Monday, Cleveland’s only run came on a Jhonkensy Noel single that scored Gabriel Arias. SP Gavin Williams (2-2) gave up four runs and lasted just two innings for the Guardians, who fell to 15-13 overall. 

Cleveland manager Stephen Vogt will turn to twenty-six year old righty Tanner Bibee (2-2 5.19 ERA) on Tuesday. Last time out, Bibee (6 IP) allowed two runs and struck out five batters during a 3-2 home victory versus New York. 

Minnesota 3B Royce Lewis (hamstring) is on a rehab assignment with Triple-A St. Paul and is expected to rejoin the club early next month. Through 29 games, Minnesota ranks 22nd in OPS and 21st in runs scored. For the season, Cleveland ranks 18th in OPS and 20th in runs scored. Take the under. Final Score Prediction, Cleveland Guardians win 5-2.