Twins vs Guardians Picks and Prediction – 4/30/2025

On Wednesday, the Minnesota Twins will play the third game of a four-game series on the road versus the Cleveland Guardians. Minnesota is 13-16 following its 11-1 win over Cleveland in the first game of the series on Monday. Minnesota collected 17 hits to win for the fourth straight time and sixth in the last seven. Minnesota trails first-place in the American League Central by five games. Keep up to date with all the MLB action with our MLB predictions.

Ty France is batting .248 to lead Minnesota and has a team-high .330 on-base percentage. Byron Buxton is the leader in home runs with six, RBI with 17, and hits with 25. Minnesota is batting .234 with a .371 slugging percentage. On Wednesday, the Minnesota Twins will send Pablo Lopez to the mound. The right-hander is 2-1 with a 2.08 ERA, 20 Ks, and 4 BBs.

The Cleveland Guardians dropped to 15-13 following Monday’s 10-run loss to Minnesota. Cleveland gave up 17 hits to Minnesota in Monday's loss while generating only eight of their own. Gavin Williams suffered the loss, allowing four runs on seven hits in just 2.0 innings. Cleveland is second in the AL Central, 2 ½ games behind the first-place Detroit Tigers. 

Steven Kwan is batting .345 with 38 hits and an on-base percentage of .395 to lead Cleveland in the three categories. Kyle Manzardo is the leader in home runs with seven and in RBI with 18. Cleveland is batting .237 with a .381 slugging percentage. On Wednesday, the Guardians will send Luis Ortiz to the mound. The right-hander is 2-3 with a 5.96 ERA, 31 Ks, and 14 BBs. 

Minnesota has won six of the last seven, which includes Monday’s victory in the first game of this series, while Cleveland has dropped four of its last five. Minnesota starter Pablo Lopez has had four consecutive solid outings, allowing five runs on 20 hits across 21.2 innings. Cleveland starter Luis Ortiz is coming off a poor outing in which the right-hander allowed four runs on five hits across 4.1 innings. Final Score Prediction: Minnesota Twins win 6-2.