Brewers vs Cardinals Picks and Prediction – 4/26/2025

By: David Anicetti |

Last Updated: 04/24/2025 at 8:10 PM ET

Milwaukee Brewers at St. Louis Cardinals 04/25/25 - MLB Picks & Predictions
Game Start: 4/26/2025, 12:15 AM UTC
Latest Odds: STL -125 ; O/U 8

Brewers vs Cardinals Prediction

The Milwaukee Brewers open a three-game series on the road Friday versus the St Louis Cardinals. Milwaukee is 13-12 following its 4-2 loss to the San Francisco Giants on Wednesday. Milwaukee has lost two of the first three versus San Francisco and completes that series on Thursday. The Brewers are second in the National League Central, 2 ½ games behind the first-place Chicago Cubs. Keep up to date with all the MLB action with our expert MLB picks.

Brice Turang is batting .350 with 35 hits to lead Milwaukee in both categories. Christian Yelich is the leader in home runs with five, while Jackson Chourio is the leader in on-base percentage, and Sal Frelick is the leader in on-base percentage at .406. On Friday, Milwaukee will send Chad Patrick to the mound. The right-hander is 1-1 with a 2.11 ERA, 20 Ks, and 9 BBs.

The St Louis Cardinals dropped to 10-15 following Wednesday’s 4-1 loss to the Atlanta Braves. St Louis lost two out of three to Atlanta in its just-completed series, and the Cardinals have dropped six of the last seven. St Louis is last in the National League Central, 5 ½ games behind the first-place Chicago Cubs.

Brendan Donovan is batting .356 to lead St Louis and has team highs in hits with 32 and on-base percentage with .392. Ivan Herrera is the leader in home runs with four, and Lars Nootbaar is the leader in RBI with 14. On Friday, the St Louis Cardinals will send Matthew Liberatore to the mound. The left-hander is 1-2 with a 3.60 ERA, 24 Ks, and 2 BBs.

Brewers vs Cardinals Pick Analysis

Milwaukee and St Louis have scored plenty of runs to start the season, but both will have starting pitchers on the mound who have performed well through the first few weeks of the regular season. Therefore, the play here is UNDER. Milwaukee starter Chad Patrick had five solid starts, allowing five runs across 21.1 innings. St Louis starter Matthew Liberatore has had two consecutive strong outings, allowing two runs across 12.2 innings. Final Score Prediction: Milwaukee Brewers win, but our best play is UNDER 5-2.

Our Free MLB Pick for St. Louis Cardinals vs Milwaukee Brewers

Under 8