Brewers vs Giants Picks and Prediction – 4/24/2025

The Milwaukee Brewers (12–11) continue their road trip with a marquee pitching matchup against the red-hot San Francisco Giants (15–8) on Wednesday night at Oracle Park. First pitch is scheduled for 9:45 PM ET. After dropping the series opener 5–2, Milwaukee looks to even things up, while the Giants aim to extend their early-season dominance, particularly at home. Get in on the action with our free MLB picks.

The Brewers enter Wednesday’s game sitting just above .500, backed by a pitching staff that has carried them through a wave of injuries. Right-hander Freddy Peralta (2–1, 1.91 ERA) will get the start, having struck out 28 batters across 28.1 innings while posting a 0.95 WHIP. Offensively, the team has been inconsistent, averaging 4.43 runs per game with a team batting average of .235. Outfielder Jackson Chourio leads the club in RBIs (19), while Sal Frelick paces the lineup with a .338 batting average. Milwaukee has managed a 6–6 road record and is 2–2 on their current West Coast trip.

The Giants have stormed out to a 15–8 record thanks to dominant home pitching and timely hitting. Ace Logan Webb (2–1, 2.40 ERA) will take the mound after a hot start to 2025, recording a 1.13 WHIP and 26 strikeouts in 30 innings. He owns a 2.61 career ERA against the Brewers. San Francisco’s offense is led by Wilmer Flores, who has been a powerhouse with 7 homers and 24 RBIs. The Giants are 8–3 at home and have won five of their last six games overall, asserting themselves as early contenders in the NL West.

Wednesday’s matchup features two of the NL’s most efficient starters in Peralta and Webb, suggesting a low-scoring affair. The Brewers are fighting through roster challenges, while the Giants have been sharp on both sides of the ball. We think the Giants handle a weak Brewer offense and take this one 4-2.