Brewers vs Giants Picks and Prediction – 4/22/2025

The Milwaukee Brewers open a four-game series on the road Monday versus the San Francisco Giants. Milwaukee is 11-10 following its 3-1 loss to the Athletics on Saturday. Milwaukee has split the first two games of its series with the Athletics, which concludes on Sunday. Milwaukee is second in the National League Central, two games behind the first-place Chicago Cubs. Keep up to date with all the MLB action with our expert MLB picks.

Sal Frelick is batting .319 with a .410 on-base percentage to lead Milwaukee in both. Jackson Chourio leads Milwaukee in home runs with five and in RBI with 18. Brice Turang is the leader in hits with 26. Milwaukee is batting .230 with a .369 slugging percentage. On Monday, Milwaukee will send Quinn Priester to the mound. The right-hander is 1-0 with a 0.90 ERA, 8 Ks, and 5 BBs. 

The San Francisco Giants improved to 14-7 following Saturday’s 3-2 victory over the Los Angeles Angels. San Francisco starter Landen Roupp struck out nine in seven innings, and Matt Chapman hit a two-run homer. San Francisco snapped a two-game losing streak with Saturday’s win. The Giants are third in the National League West, one game behind the first-place San Diego Padres. 

Jung Hoo Lee is batting .355 with 27 hits and an on-base percentage of .412 to lead San Francisco in each of the categories. Wilmer Flores is the leader in home runs with six and in RBI with 23. San Francisco is batting .223 with a slugging percentage of .397. On Monday, San Francisco will send Robbie Ray to the mound. The left-hander is 3-0 with a 4.19 ERA, 21 Ks, and 15 BBs.

Milwaukee has won eight of its last 11, and the Brewers are 4-5 on the road, while San Francisco is just 2-4 at home. Milwaukee starter Quinn Priester has had two strong outings, allowing one run on seven hits across 10 innings for a 0.90 ERA. San Francisco starter Robbie Ray was hit hard last time out, allowing four runs on six hits across four innings with five walks. Final Score Prediction: Milwaukee Brewers win 6-4.