Marlins vs Padres Picks and Prediction – 5/28/2025

The Miami Marlins complete a three-game series on the road Wednesday versus the San Diego Padres. Miami dropped to 21-31 following Monday’s 4-3 loss to San Diego in the opening game of the series. Miami's short two-game winning streak was snapped by the loss, and the Marlins have lost four of the last six. Miami is last in the National League East, 12 ½ games behind the first-place Philadelphia Phillies. Keep up to date with all the MLB action with our MLB predictions.

Kyle Stowers is batting .300 with 10 home runs, 31 RBI, 54 hits, and an on-base percentage of .369 to lead Miami in the five categories. Matt Mervis is second in home runs with seven and Liam Hicks is second in RBI with 21. On Wednesday, the Miami Marlins will send Sandy Alcantara to the mound. The right-hander is 2-7 with an 8.04 ERA, 40 Ks, and 25 BBs.

The San Diego Padres improved to 30-22 with Monday’s one-run victory over Miami. Manny Machado tied the score with a home run in the eighth, and Tyler Wade scored on a wild pitch in the 11th inning by Miami’s Cade Gibson to win the game. San Diego has won two straight and three of the last four. The Padres are second in the National League West, two games behind first-place Los Angeles.

Manny Machado is batting .319 with 61 hits and an on-base percentage of .391 to lead San Diego in the three categories. Fernando Tatis Jr is the leader in home runs with 12. Gavin Sheets is the leader in RBI with 31. San Diego is batting .251 with a .388 slugging percentage. On Wednesday, San Diego will send Kyle Hart to the mound. The left-hander is 2-2 with a 6.00 ERA, 16 Ks, and 16 BBs.

The UNDER has cashed more often than not amongst these two, but with two struggling starting pitchers on the mound, the play here is OVER. Miami starter Sandy Alcantara has been hit hard in five consecutive outings, allowing 25 runs across 23.2 innings. San Diego starter Kyle Hart has been hit hard in four of the last five outings, allowing 14 runs across 21 innings. Final Score Prediction: San Diego Padres win but our best play is OVER 7-5.