Dodgers vs Guardians Picks and Prediction – 5/27/2025

The Tuesday MLB schedule will get started with an interleague matchup between the Los Angeles Dodgers and the Cleveland Guardians. Be ready for the baseball season with all of our MLB predictions. The Dodgers (33-21) are a game above .500 on the road and hold a two-game lead over San Francisco for NL West Division supremacy. Last night, MVP Shohei Ohtani led off the game with a home run and scored three times to spark Los Angeles to a 7-2 road triumph against Cleveland.

Twenty-seven year old righty Dustin May (2-4 4.09 ERA) will make his tenth start of the year for the Dodgers. Last time out, May (6 IP) allowed one run and struck out eight batters during a 3-1 home victory versus Arizona. 

The Cleveland Guardians have split their previous ten games and are five games back in the AL Central Division race. During Monday’s home loss, All-Star 3B Jose Ramirez collected two of Cleveland’s six hits and drove in a run. SP Gavin Williams (4-3) walked six batters and gave up four runs in a losing effort for the Guardians (29-24), who fell to 14-9 at home.   

The Guardians will counter with twenty-six year old righty Tanner Bibee (4-4 3.57 ERA) on Tuesday. In his last start, Bibee fired seven shutout frames and fanned eight batters during a 7-0 road triumph against Detroit. 

Los Angeles SP Tyler Glasnow (shoulder) threw a bullpen session on Friday and hopes to rejoin the rotation next month. Through 54 games, Los Angeles ranks 2nd in OPS and 3rd in runs scored. For the season, Cleveland ranks 24th in OPS and 23rd in runs scored. Take the Guardians to win at home. Final Score Prediction, Cleveland Guardians win 5-3.