Dodgers vs Cubs Picks and Prediction – 4/22/2025

This Tuesday, Dustin May and the Los Angeles Dodgers head to Wrigley Field to take on Shota Imanaga and the Chicago Cubs in a National League showdown. Get our free MLB Picks all season long! The Dodgers, now 16-7, are coming off a narrow 1-0 win over the Texas Rangers on Sunday, showcasing strong pitching and late-inning resilience.

May has been dominant early in the season, flashing his elite velocity and sharp breaking stuff. He’ll look to continue his form against a Cubs lineup that has been solid but has struggled at times with strikeouts and clutch hitting. The Dodgers’ deep order will aim to give May some early run support.

Chicago enters at 14-10 after a tough 3-2 loss in 11 innings to the Diamondbacks on Sunday. Imanaga has been one of the league’s early standouts, sporting elite command and run prevention since arriving from Japan. He’ll face his toughest test yet in a Dodgers offense stacked with power and patience.

This game will likely hinge on which pitcher can work deeper into the game with minimal traffic. The Cubs will need to manufacture runs and stay aggressive on the bases, while Los Angeles will look for a big swing to change momentum quickly.

With May in top form and the Dodgers’ offense able to break out at any time, Los Angeles has the edge in this pitching duel. Imanaga will keep it close, but the Dodgers’ lineup depth will prove the difference. Take the Dodgers to win this one on the road. Final Score Prediction, Los Angeles Dodgers win 3-1.