Angels vs Cardinals Picks and Prediction – 4/2/2025

By: David Anicetti |

Last Updated: 04/01/2025 at 8:45 PM ET

Los Angeles Angels at St. Louis Cardinals 04/02/25 - MLB Picks & Predictions
Game Start: 4/2/2025, 5:15 PM UTC
Latest Odds: STL -145 ; O/U 8.5

Angels vs Cardinals Prediction

The Los Angeles Angels conclude a three-game series on the road Wednesday versus the St. Louis Cardinals. Los Angeles is 3-1 and leads the American League West by a half-game over the Texas Rangers. Los Angeles defeated St. Louis 5-4 in the opening game of the series on Monday. Kyren Paris’ triple in the 7th inning broke a tie to help lead the Angels to the win. Keep up to date with all the MLB action with our MLB picks.

Nolan Schanuel is batting .294 with five hits to lead Los Angeles in both categories. Logan O’Hoppe is the leader in home runs with one, and Mike Trout is the leader in RBI with two. The Angels have a team batting average of .185 and a slugging percentage of .266. On Wednesday, Los Angeles will send Yusei Kikuchi to the mound. The left-hander is 0-1 with a 4.50 ERA, 5 Ks, and 0 BBs.

The St Louis Cardinals are 3-1 and first in the National League Central, one game ahead of the Cincinnati Reds. St Louis had its three-game winning streak to open the regular season snapped in their one-run loss to Los Angeles on Monday. Despite the loss, St Louis continues to have early season success on the mound as the Cardinals are fifth in team ERA at 2.43

Lars Nootbar is batting .462 to lead St Louis and has team highs in home runs with two, RBI with five, and on-base percentage of .632. Nolan Arenado is the leader in hits with six. St Louis has a team batting average of .301 and a slugging percentage of .382. On Wednesday, the Cardinals will send Sonny Gray to the mound. The right-hander is 1-0 with a 3.60 ERA, 6 Ks, and 2 BBs.

Angels vs Cardinals Pick Analysis

St Louis has won three of its first four and is receiving strong production both at the plate and on the mound early this season. Los Angeles starter Yusei Kikuchi gave up three runs on five hits across six innings when losing to the Chicago White Sox on opening day. St Louis starter Sonny Gray gave up just two runs on four hits across five innings on opening day when defeating Minnesota 5-3. Final Score Prediction, St Louis Cardinals win 5-3.

Our Free MLB Pick for St. Louis Cardinals vs Los Angeles Angels

St. Louis Cardinals -145