Angels vs Padres Picks and Prediction – 5/15/2025

The San Diego Padres remain at home on Wednesday with the Los Angeles Angels in town. The Padres are 2nd in the NL West. San Diego has won six of their last ten games and carry a 14-5 home field record. The Padres are averaging 4.6 runs scored per game with 8.9 hits. Stay up to date with our expert's MLB Picks. 

Randy Vasquez will make his 9th start on the mound for the San Diego Padres. Vasquez is 2-3 on the season with 38.1 innings pitched. Vasquez has 18 strikeouts and carries a 3.76 ERA. Vasquez pitched 6 innings in his last start allowing 2 runs on 6 hits. 

The Los Angeles Angels are last in the AL West. The Angels have won five of their last ten games and carry a 8-13 road record. Los Angeles is averaging 3.8 runs scored per game with 7.1 hits. The Angels beat the Padres 9-5 on MOnday. 

Kyle Hendricks will make his 8th start on the mound for the LA Angels. Hendricks is 1-4 on the season with 35.2 innings pitched. Hendricks has 21 strikeouts and carries a 5.30 ERA. Hendricks pitched 5 innings in his last start allowing 3 runs on 6 hits. 

The San Diego Padres head into Wednesday as heavy home favorites. Kyle Hendricks has allowed 11 earned runs over his last three starts for the LA Angels. The Angels carry a 5.14 team ERA. The value is in the total. Final Score Prediction, San Diego Padres win, but the play is on the over 6-5.