Angels vs Guardians Picks and Prediction – 5/31/2025

By: David Anicetti |

Last Updated: 05/30/2025 at 8:32 PM ET

Los Angeles Angels at Cleveland Guardians 05/31/25 - MLB Picks & Predictions
Game Start: 5/31/2025, 8:10 PM UTC
Latest Odds: CLE -183 ; O/U 8

Angels vs Guardians Prediction

The Los Angeles Angels will play the second game of a three-game series on the road Saturday versus the Cleveland Guardians. Los Angeles is 25-30 following Wednesday’s 1-0 loss to the New York Yankees. The Angels were off on Thursday. Los Angeles has lost five straight. The Angels are five games behind the first-place Seattle Mariners in the American League West. Keep up to date with all the MLB action with our expert MLB picks.

Nolan Schanuel is batting .273 with 50 hits and an on-base percentage of .368 to lead Los Angeles in the three categories. Taylor Ward is leading Los Angeles in home runs with 15 and RBI with 37. Los Angeles is batting .224 with a .404 slugging percentage. On Saturday, Los Angeles will send Kyle Hendricks to the mound. The right-hander is 2-6 with a 5.23 ERA, 33 Ks, and 16 BBs.

The Cleveland Guardians are 30-25 following Wednesday’s 7-4 victory over the Los Angeles Dodgers. Angel Martinez hit a three-run homer in the eighth for Cleveland to help the Guardians avoid being swept in their series with Los Angeles. The win snapped a three-game losing streak. Cleveland was off on Thursday. Cleveland is tied with Minnesota for second place in the American League Central, six games behind the first-place Detroit Tigers.

Jose Ramirez is batting .318 to lead Cleveland, while Steven Kwan has team highs in hits with 66 and on-base percentage at .371. Kyle Manzardo is the leader in home runs with 10 and in RBI with 28. Cleveland is batting .233 with a .378 slugging percentage. On Saturday, Cleveland will send Slade Cecconi to the mound. The right-hander is 1-1 with a 3.27 ERA, 14 Ks, and 2 BBs.

Angels vs Guardians Pick Analysis

Cleveland will win on Saturday at home when hosting Los Angeles, but the play here is UNDER. The UNDER has cashed in each of the Angels’ last five. Los Angeles starter Kyle Hendricks has had four consecutive below-par outings, allowing 13 runs across 22.2 innings, but three of the four cashed UNDER. Cleveland starter Slade Cecconi has had two solid outings, allowing four runs across 11 innings, with both cashing UNDER. Final Score Prediction: Cleveland Guardians win but our best play is UNDER 4-2.

Our Free MLB Pick for Cleveland Guardians vs Los Angeles Angels

Under 8