Royals vs Cardinals Picks and Prediction – 6/4/2025

The Kansas City Royals (31-29) head to Busch Stadium to face the St. Louis Cardinals (33-26) on Wednesday at 5:45 PM EST. This game wraps up the series and features a southpaw vs righty pitching duel between Noah Cameron (2-1, 1.05 ERA) and Miles Mikolas (4-2, 3.90 ERA). Kansas City is coming off a 1-0 loss to Detroit, while St. Louis just got hammered by Texas 8-1. Elevate your MLB game with our top-notch MLB picks.

Kansas City has dropped three of its last five and has been inconsistent at the plate. They were shut out twice in the recent Detroit series and struggled with run production. Bobby Witt Jr. remains the most dangerous bat, driving in 31 runs with a .283 average, while Vinnie Pasquantino leads in home runs with 8. Kansas City’s offense ranks near the middle of the pack with a .247 average, 34 homers, and a .300 OBP.

On the mound, the Royals are a different story. They're posting a 3.13 team ERA and 1.18 WHIP, among the best in the league. Opponents are hitting just .233 against them. Noah Cameron’s been excellent with a 1.05 ERA in 25.2 innings, and even with a few arms on the IL like Cole Ragans and Alec Marsh, the pitching staff has held strong. The Royals' road record of 12-16 is the main concern heading into this one.

St. Louis has won three of its last five but got roughed up badly in the finale against Texas. Offensively, the Cardinals are more balanced. Brendan Donovan leads with a .323 average, while Lars Nootbaar has 8 home runs. The club is hitting .258 with 52 home runs and a .328 OBP. They’re much better at home (19-8), which gives them a solid edge in this matchup.

On the hill, St. Louis holds a 3.78 ERA and a 1.24 WHIP. Mikolas has been serviceable with 55.1 innings pitched, allowing just 3 homers and sporting a 1.25 WHIP. Injuries to Jordan Walker and key bullpen arms like Zack Thompson haven’t stopped this unit from putting together solid outings. The Cardinals are 18-12 in night games and typically capitalize at Busch Stadium.

The Royals are throwing the hottest pitcher on the staff in Noah Cameron, who’s been lights out so far. St. Louis has better overall numbers offensively, but Mikolas has been up-and-down, and the Royals’ pitching edge can’t be ignored. Take the visitors to win this one. Final Score Prediction: Kansas City wins 4-2.