Royals vs Cubs Picks and Prediction – 7/23/2025

The Kansas City Royals complete a three-game series on the road Wednesday versus the Chicago Cubs. Kansas City improved to 49-52 following Monday’s 12-4 victory over Chicago in the opening game of the series. Salvador Perez hit a pair of home runs and had four RBI for the Royals. Kansas City hit two other homers in the win. The Royals trail first-place Detroit in the American League Central by 11 games. Keep up to date with all the MLB action with our expert MLB picks.

Maikel Garcia is batting .293 with an on-base percentage of .347 to lead Kansas City in both categories. Salvador Perez leads Kansas City in home runs with 17 and RBI with 60, while Bobby Witt Jr leads in hits with 115. Kansas City is batting .245 with a .379 slugging percentage. On Wednesday, Kansas City will send Seth Lugo to the mound. The right-hander is 6-5 with a 2.94 ERA, 93 Ks, and 31 BBs.

The Chicago Cubs dropped to 59-41 following Monday’s eight-run loss to Kansas City, which was Chicago's second consecutive loss since having its four-game winning streak snapped. Chicago is second in runs scored and 13th in ERA. The Cubs were knocked out of first place in the National League Central on Monday and trail first-place Milwaukee by one game. 

Michael Busch is batting .285 to lead Chicago, while Nico Hoerner leads the Cubs in hits with 104. Seiya Suzuki is the leader in home runs with 26 and RBI with 80. Kyle Tucker has a .382 on-base percentage to lead the Cubs. On Wednesday, Chicago will send Colin Rea to the mound. The right-hander is 8-3 with a 3.80 ERA, 70 Ks, and 27 BBs.

The Chicago Cubs will win at home on Wednesday when completing a three-game series against the Kansas City Royals, but the play here is UNDER. The UNDER has cashed in seven of Chicago's last 10 and 8 of Chicago's last 11 versus an opponent from the American League. Chicago starter Colin Rea had had three straight strong outings, allowing three runs on nine hits across 18.2 innings. Final Score Prediction: Chicago Cubs win but our best play is UNDER 5-2.