Astros vs Cardinals Picks and Prediction – 4/16/2025

In Wednesday afternoon MLB action, the Houston Astros and the St. Louis Cardinals will wrap up their interleague series from Busch Stadium. Be ready for the baseball season with all of our MLB predictions. The Astros (8-9) have split their first eight road games and are two games back of Los Angeles for first place in the AL West Division standings. Last night, a Jake Meyers run-scoring single and a Yordan Alvarez solo shot was all the offense Houston would need during a 2-0 road victory. 

Thirty-one year old righty Ronel Blanco (1-1 6.94 ERA) will head to the hill for the Astros in this contest. In his last start, Blanco (5 IP) allowed two runs and struck out seven batters during a 14-3 home victory versus Los Angeles. 

The St. Louis Cardinals have won seven of their first 11 home games and trail Chicago by two games for the top spot in the NL Central Division. On Tuesday, St. Louis batters went 1-for-7 with runners in scoring position and left six men on base. SP Erick Fedde (1-2) gave up one run in six innings and was the hard-luck loser for the Cardinals (8-9).

Thirty-three year old southpaw Steven Matz (0-0 2.31 ERA) will make his first start of the season for the Cardinals. Matz has worked 11 plus innings of relief and has not surrendered a home run while posting a solid 1.11 WHIP.

Houston SP Cristian Jaiver (elbow) has been transferred to the 60-day injured list and is not eligible to return until after the All-Star Break. Through 17 games, Houston ranks 22nd in OPS and 20th in runs scored. For the regular season, St. Louis ranks 1st in OPS and 3rd in runs scored. Take the Cardinals to win at home. Final Score Prediction, St. Louis Cardinals win 6-2.