Astros vs Athletics Picks and Prediction – 6/19/2025

The Houston Astros (41–31) head North for a midweek clash at AL West rival Sacramento Athletics (30–44). First pitch is set for 10:05 PM ET under stadium lights. Houston looks to build on a dominant 5-game winning streak, while Sacramento rides momentum from a 4-game home winning streak. Both teams need a boost—Houston to maintain its division lead, Sacramento to climb out of the cellar. Get in on the action with our free MLB picks.

The Astros bring consistent firepower, winning 8 of their last 10 games. Despite a modest 14–18 road record, they are supported by a potent lineup: Jeremy Peña is scorching hits in June (.379 avg, .883 OPS), and Isaac Paredes has 15 HR . Houston's rotation and bullpen remain solid (3.43 ERA staff, 11.9 K/9) . However, they’re dealing with injuries—outfielder Jacob Melton (ankle) and 3B Isaac Paredes (hamstring) are sidelined. They'll rely on depth and veteran resilience to overcome adversity.

Sacramento has surprised fans with a 4-game winning streak, including a sweep last night. They're riding home-field strength (13–23) with contributions from Brent Rooker (15 HR) and Rookie Nick Kurtz, who just hit a walk-off homer. The Athletics pitching staff struggles (5.42 team ERA, 1.49 WHIP), and Luis Severino, who is potentially the most talented pitcher on the roster (although his 4.47 ERA is not too shiny) is on the mound.

This series sees two teams riding different waves—Houston with star power, Sacramento with scrappy resolve. Expect some fireworks early, but Houston’s offense and pitching edge should prevail in a close one. We we like the Astros to secure a victory, and even cover the run line for some extra value. Take Houston to win 6-4.