Astros vs Pirates Picks and Prediction – 6/3/2025

Scenic PNC Park will play host to a Tuesday night MLB interleague clash between the Houston Astros and the Pittsburgh Pirates. Be ready for the baseball season with all of our MLB predictions. The Astros (32-27) have won seven of their last ten games and trail Seattle by a half-game for the top spot in the AL West Division. On Sunday, SP Ben Brown (8-3) allowed one hit across six shutout frames to lead Houston to a 1-0 home victory versus Tampa Bay. 

Thirty-one year old righty Lance McCullers Jr. (0-1 5.89 ERA) will take the mound for the Astros in this matchup. In his last start, McCullers Jr. (6 IP) allowed three runs and fanned 12 batters during a 5-3 home victory versus the Athletics. 

The Pittsburgh Pirates are three games below .500 at home and are trying to climb out of the NL Central Division cellar. On Sunday, Pittsburgh OF Andrew McCutchen and 2B Adam Frazier each went deep during a 6-4 road loss against San Diego. SP Andrew Heaney gave up two runs in five plus innings and did not factor in the decision for the Pirates (22-38)\.

NL Rookie of the Year Paul Skenes (4-5 2.15 ERA) is showing no signs of a sophomore slump for the Pirates. Through 75 plus innings, Skenes has struck out 77 batters and ranks fifth in the majors with a 0.92 WHIP.

Houston OF Yordan Alvarez’s fractured hand is not fully healed and he will be shut down from hitting. Through 59 games, Houston ranks 20th in OPS and 19th in runs scored. For the season, Pittsburgh ranks 27th in OPS and 28th in runs scored. Take the under. Final Score Prediction, Pittsburgh Pirates win 4-2.