Astros vs Twins Picks and Prediction – 4/6/2025

The Houston Astros (3-5) are set to face the Minnesota Twins (3-5) at Target Field in Minneapolis on Sunday, April 6, 2025. The first pitch is scheduled for 2:10 PM ET, with the game broadcast on Twins.TV. ​Get in on all the baseball action with our free MLB picks.

The Astros aim to rebound after a 6-1 loss to the Twins on Saturday. In that game, José Altuve provided an early lead with a solo home run in the first inning, but the offense was limited thereafter. Starting pitcher Spencer Arrighetti allowed five runs over 3.2 innings, and the bullpen conceded an additional run. ​

Right-hander Ronel Blanco is slated to start for Houston. Blanc, so far, has posted a 5.40 ERA over five innings, with a WHIP of 1.20 and a strikeout rate of 10.8 K/9. ​

The Twins capitalized on a six-run fourth inning in Saturday's victory, highlighted by José Miranda's three-run homer. The offense totaled six hits and drew four walks, while the pitching staff held the Astros to one run. ​

Right-hander Chris Paddack will take the mound for Minnesota. In his season debut, Paddack struggled, allowing nine earned runs over 3.1 innings, resulting in a 24.30 ERA and a WHIP of 3.00. 

This matchup features two teams seeking to improve their early-season records. The Astros will look to capitalize on Paddack's recent struggles, and that is the reason Houston will take this final game in the series. We will be backing Houston to clobber the Twins and win this by a score of 6-2.