Astros vs Twins Picks and Prediction – 4/5/2025

The Houston Astros play the second game of a three-game series on the road Saturday versus the Minnesota Twins. Houston is 3-4 and 3rd in the American League West, two games behind the first-place Texas Rangers. Houston won the opening game of the series with Minnesota on Thursday 5-2, snapping a three-game losing streak. Jeremy Pena and Christian Walker each homered for the Astros. Keep up to date with all the MLB action with our MLB picks.

Jose Altuve is batting .321 with nine hits and an on-base percentage of .367 to lead Houston in each of the three categories. Jeremy Pena is the leader in home runs with two and Yordan Alvarez has a team-best four RBI. Houston has a team batting average of .191 and a slugging percentage of .270. On Saturday, Houston will send Spencer Arroghetti to the mound. The right-hander is 1-0 with a 1.50 ERA, 5 Ks, and 2 BBs. 

The Minnesota Twins look to bounce back from their three-run loss to Houston in the opening game of this series with a win at home on Saturday. Minnesota is 2-5 following its loss to the Astros and is last in the AL Central. Minnesota opened the season losing four straight, followed by two wins, before losing on Thursday night to the Astros.

Willi Castro is batting .261 with an on-base percentage of .346 to lead Minnesota in both categories. Harrison Bader leads Minnesota in home runs with three and RBI with eight, while Byron Buxton is the leader in hits with six. Minnesota has a team batting average of .180 and a slugging percentage of .294. On Saturday, Minnesota will send Bailey Ober to the mound. The right-hander is 0-1 with a 27.00 ERA, 3 Ks, and 3 BBs.

Houston has a big advantage on the mound Saturday related to starting pitchers. Houston starter Spencer Arrighetti performed well last time out, allowing one run on one hit across six innings in a 2-1 victory. Minnesota starter Bailey Ober struggled last time out, allowing eight runs on eight hits in just 2.2 innings. Minnesota has lost nine of its last 11 including five of the first seven this season. Final Score Prediction, Houston Astros win 6-2.