Astros vs Angels Picks and Prediction – 6/21/2025

The Houston Astros will be on the road again Friday night for game one of three in Los Angeles against the Los Angeles Angels. Houston has 43 wins and 31 losses on the year coming into this matchup having won four of the last five including two in a row after a 7 run victory on the road against the Athletics. Offensively Houston has a .259 batting average having scored 317 runs on 641 hits this season. The Houston pitching has also been top tier this year with a 3.42 team ERA. Stay in the action with our MLB Picks.

Jeremy Pena leads the Houston offense this season with a .321 batting average and 92 hits. Jose Altuve has a .277 batting average and Jake Meyers has a .300 batting average but has played in just 72 games. Isaac Paredes has leads Houston this season with 15 home runs and 44 RBIs across 70 games played.

The Los Angeles Angels return home Friday two games below .500 on the year having dropped two of the last five following a four run loss on the road in New York to end a three-game winning streak. Offensively Los Angeles has been terrible this season with a .26 batting average the Angels have scored just three hundred runs on 548 hits. The Los Angeles pitching has been terrible as well with a 4.63 team ERA this season.

Jacob Wilson leads the Athletics offense this season with .359 batting average and 99 hits on the year. Lawrence Butler has a .254 batting average and Shea Langeliers has a .237 batting average. Brent Rooker has a .275 batting average and leads the Athletics with 15 home runs this season. Tyler Soderstrom has a .250 batting average and has boasted a team leading 45 RBIs this year.

The Astros are the better team in this game and will play to their strengths on Friday. Look for Houston to back their starter in this game leading to the win. The Astros have been playing the better baseball as of late and will ride that momentum into this game. Final Score Prediction, Houston Astros win 5-2.