Astros vs Guardians Picks and Prediction – 6/7/2025

The Houston Astros play the second game of a three-game series on the road Saturday versus the Cleveland Guardians. Houston improved to 34-28 following Thursday’s 8-2 win over Pittsburgh following a long rain delay. The Astros have won three of the last four, and Houston is leading the American League West by 1 ½ games over the Seattle Mariners. Keep up to date with all the MLB action with our MLB predictions.

Jeremy Pena is batting .318 with 75 hits and a .378 on-base percentage to lead the Astros in the three categories. Isaac Paredes is the leader in home runs with 14 and in RBI with 37. Houston is batting .252 with a .391 slugging percentage. On Saturday, the Houston Astros will send Hunter Brown to the mound. The right-hander is 8-3 with a 1.83 ERA, 84 Ks, and 20 BBs.

The Cleveland Guardians are 33-28 following Thursday’s 4-0 loss to the New York Yankees. Cleveland lost two out of three to the American League East-leading Yankees. Cleveland is 4-6 in its last 10. The Guardians are third in the American League Central, 6 ½ games behind the first-place Detroit Tigers and just a half-game behind second-place Minnesota.

Jose Ramirez is batting .330 with 11 home runs, 74 hits, and an on-base percentage of .384 to lead Cleveland in the four categories. Carlos Santana is the leader in RBI with 29. Cleveland is batting .235 with a .377 slugging percentage. On Saturday, the Cleveland Guardians will send Gavin Williams to the mound. The right-hander is 5-3 with a 3.79 ERA, 66 Ks, and 34 BBs.

Houston has won eight of its last 11, and the Astros have won seven of the last eight versus Cleveland. The Guardians have lost six of the last 10 overall. Houston starter Hunter Brown has pitched well in each of the last two outings, allowing one run on seven hits across 12 innings. Brown leads the American League in wins with eight and has an ERA of just 1.83. Final Score Prediction: Houston Astros win 5-1.